Genes Identified by GWAS


Step1: select a GWAS

CLOZUK             PGC2

Step2: input genes

or - Input a region

Step2: input a region

- bp
CACNA1C
SPATS2L
LINC00862
MIR6773
BDNF
YAP1

or - Input a region

Chromosome chr16
Genome Position 67708897 - 68305708 bp

Where does this data come from?

    In 2014, the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) reported a multi-stage schizophrenia genome-wide association study (PGC2 GWAS) of up to 36,989 cases and 113,075 controls. They identified 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance (Schizophrenia Working Group of the Psychiatric Genomics Consortium. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510):421-427. [PMID: 25056061]). The Tagged genes in these loci were collected into this database as PGC2 GWAS genes.
    In 2018, Pardiñas et al. reported a new genome-wide association study of schizophrenia (CLOZUK GWAS; 11,260 cases and 24,542 controls), and through meta-analysis with independent PGC datasets they identified 50 novel associated loci and 145 loci in total associated with schizophrenia (Pardiñas et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 50(3):381-389. [PMID: 29483656]). The Tagged genes in these loci were collected into this database as CLOZUK GWAS genes.
    It should be noted that these two GWAS studies were not fully independent.
    If you used this data, please cite the reletive reference.