Genes expressed differentially in Schizophrenia

Step1: Input genes


Where does this data come from?

We Downloaded this data from CommonMind Consortium (CMC; CMC is a public-private partnership to generate functional genomic data in brain samples obtained from autopsies of individuals with and without severe psychiatric disorders. In the original study, CMC collected post-mortem dorsolateral prefrontal cortex (DLPFC) tissues from 258 subjects with schizophrenia and 279 controls from Caucasian, African-American, Hispanic and East Asian ancestries. Then the RNA was extracted and RNA-seq was performed after depleting ribosomal RNA. Fromer et al. performed the differential expression analysis with Limma package using normalized expression with adjustment for covariates. More details about the CMC description and data analysis procedure can be found in the original publication. (Fromer et al. 2016. Gene expression lucidates functional impact of polygenic risk for schizophrenia. Nature Neuroscience, 19(11):1442-1453 [PMID: 27668389]).
If you used this data, please cite the original paper of CMC ([PMID: 27668389]).