Polygenic Risk Score Calculator

Step1: select a GWAS

CLOZUK             PGC2

Step2: upload genotype files

Plink binary bed file format
Plink binary bim file format
Plink binary fam file format

Step1: select a method

PRSice-2             PRS-CS
Example for genotype files


If you used this tool, please cite the reletive reference.
PGC2 GWAS: Schizophrenia Working Group of the Psychiatric Genomics Consortium. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510):421-427. [PMID: 25056061]
CLOZUK GWAS: Pardiñas et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 50(3):381-389. [PMID: 29483656]
PRSice-2: Choi et al. 2019. PRSice-2: Polygenic Risk Score Software for Biobank-Scale Data. GigaScience, 8(7):giz082. [PMID: 31307061]
PRS-CS: Ge et al. 2019. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nature Communications, 10(1):1776. [PMID: 30992449]