SLC6A3

Basic Information
Gene SymbolSLC6A3
Entrez Id6531
Positionchr5:1392905..1445543
Descriptionsolute carrier family 6 (neurotransmitter transporter), member 3
Gene typeprotein-coding
SNP Information

SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*
rs100364785:1437898T/CSLC6A3intron0.9640.988860.01130.32274
rs100408825:1418558T/CSLC6A3intron0.9101.012380.01330.3547
rs100513405:1426166C/GSLC6A3intron0.9640.990740.01280.47096
rs100520165:1428111A/GSLC6A3intron0.9470.999100.01250.94497
rs100536025:1428135T/CSLC6A3intron0.9640.990350.01280.4496
rs100635645:1438030A/TSLC6A3intron0.9451.009650.01300.45895
rs100688765:1438042A/GSLC6A3intron0.9451.009650.01300.45925
rs100694635:1395794A/GSLC6A3intron0.9031.018060.02150.40565
rs100728095:1439748A/GSLC6A3intron0.8671.022760.02460.36085
rs100741715:1408404A/GSLC6A3intron0.8811.003100.01300.80976
rs10420985:1394815A/GSLC6A3untranslated-30.9061.007330.01290.57025
rs104750055:1425049A/GSLC6A3intron0.9660.990350.01290.44975
rs104750065:1425235A/GSLC6A3intron0.9640.990940.01280.47697
rs10489555:1438105T/CSLC6A3intron0.9471.017550.01130.12285
rs1112511755:1422762T/CSLC6A3intron0.7760.982460.01460.22626
rs1127966375:1408349T/GSLC6A3intron0.8860.998400.01410.90927
rs1143504835:1423184A/CSLC6A3intron0.6711.003310.02550.89626
rs1150763195:1423872T/CSLC6A3intron0.6850.939510.05880.28866
rs115647625:1410613T/GSLC6A3intron0.8710.996110.01430.78475
rs1158040915:1399425A/GSLC6A3intron0.7531.058970.04480.20045
rs1164125955:1403486T/CSLC6A3intron0.8751.002500.02300.91215
rs117379015:1430616T/CSLC6A3intron0.9550.982850.01160.13495
rs117389685:1423134A/CSLC6A3intron0.7801.002600.01280.8416
rs123320915:1418745C/GSLC6A3intron0.9101.012270.01330.35717
rs131619055:1417212T/CSLC6A3intron0.9100.990450.01160.40655
rs13168305:1443990T/CSLC6A3intron0.8691.009340.01310.47626
rs131890215:1442842T/CSLC6A3intron0.7430.999800.01500.99025
rs1414050095:1422764C/GSLC6A3intron0.7411.003100.01550.8419-
rs1415922005:1414530T/GSLC6A3intron0.6631.009750.03450.7788-
rs1421997045:1437990A/CSLC6A3intron0.6621.029940.03650.4189-
rs1447823625:1431392C/GSLC6A3intron0.6830.990740.05590.8675-
rs1450366075:1436077A/GSLC6A3intron0.7300.922650.04310.06182-
rs1470535845:1406588A/GSLC6A3intron0.6100.964640.05910.5427-
rs1485903685:1409502T/CSLC6A3intron0.7701.046870.04600.3185-
rs1493120345:1417297A/GSLC6A3intron0.7821.023060.06500.7254-
rs1500520825:1419007T/CSLC6A3intron0.8160.987780.03430.7199-
rs16149195:1422549A/GSLC6A3intron0.6740.987180.01460.37735
rs1878844105:1423002A/GSLC6A3intron0.6291.032520.02250.1546-
rs1914349905:1423337T/CSLC6A3intron0.6271.000200.03250.996-
rs1914355525:1422798T/CSLC6A3intron0.7190.985210.01610.3559-
rs1929761095:1423141A/GSLC6A3intron0.6081.049070.03550.1778-
rs20424495:1416646A/GSLC6A3intron0.9081.012380.01330.35594
rs21739475:1426959A/GSLC6A3intron0.9640.990640.01280.46477
rs22456605:1409719T/CSLC6A3intron0.9421.000000.02340.9994
rs22544085:1442974A/CSLC6A3intron0.8111.006320.01180.59225
rs22709145:1442979T/CSLC6A3intron0.8291.005310.01350.69465
rs24553915:1443498A/GSLC6A3intron0.9300.986200.01260.26984
rs2469975:1440280T/GSLC6A3intron0.8331.001900.01180.87465
rs2506815:1428011T/CSLC6A3intron0.9711.021020.01080.053477
rs2506835:1426151T/CSLC6A3intron0.9760.979020.01280.097367
rs2506865:1425159T/CSLC6A3intron0.9660.979410.01080.05476
rs25509365:1411256A/CSLC6A3intron0.8621.004310.01300.74285
rs26175775:1410472T/CSLC6A3intron0.8761.005720.01290.66025
rs26176055:1442521T/CSLC6A3intron0.8790.999400.01180.95715
rs26525145:1442526A/GSLC6A3intron0.8630.995310.01300.7175
rs26525185:1429208T/CSLC6A3intron0.6640.969280.07320.66965
rs27359175:1420268A/CSLC6A3intron0.8281.007330.02470.7695
rs283630895:1412971A/GSLC6A3intron0.6191.051690.05510.36115
rs283631155:1405882T/CSLC6A3intron0.8890.996610.01420.81225
rs283631195:1405694T/CSLC6A3intron0.9531.002000.02250.92785
rs283631205:1405490T/CSLC6A3intron0.8750.994810.01440.7215
rs283631505:1400845T/CSLC6A3intron0.7110.988860.03980.77765
rs283631515:1400750A/GSLC6A3intron0.8381.035100.02310.13645
rs283631525:1400692T/GSLC6A3intron0.6591.034170.05690.55515
rs283631645:1395113T/CSLC6A3intron0.7240.980200.04000.61615
rs283631685:1394389A/CSLC6A3untranslated-30.6711.055800.04180.19335
rs283631745:1393038A/GSLC6A3untranslated-30.6661.053170.04180.21545
rs283631755:1393026A/GSLC6A3untranslated-30.6400.997500.06430.96955
rs283822215:1442757T/CSLC6A3intron0.6551.013790.02400.56965
rs283822455:1420476T/CSLC6A3intron0.9300.984130.01140.16065
rs283822465:1420382A/TSLC6A3intron0.9071.012170.01330.36065
rs283822475:1420346T/GSLC6A3intron0.9091.012270.01330.35615
rs283822485:1420306A/GSLC6A3intron0.9001.012380.01340.35695
rs283822575:1415340A/GSLC6A3intron0.7670.971320.05140.57155
rs287426085:1440934T/GSLC6A3intron0.8870.980490.02400.41375
rs29276765:1440681C/GSLC6A3intron0.8770.996010.01400.77635
rs29376385:1443973T/GSLC6A3intron0.9061.006920.01440.63176
rs29376395:1443728T/CSLC6A3intron0.9601.003000.01110.78455
rs29376405:1443604T/CSLC6A3intron0.9230.995510.01120.68585
rs29632385:1444427T/GSLC6A3intron0.9551.004410.01110.69034
rs29752235:1443603T/CSLC6A3intron0.9221.004710.01120.67475
rs29752865:1423227T/CSLC6A3intron0.6061.001800.02310.93647
rs29752925:1419932C/GSLC6A3intron0.9111.008230.01160.47955
rs29813595:1442732C/GSLC6A3intron0.6481.002600.01310.84355
rs3656635:1428883A/GSLC6A3intron0.9540.985510.01080.17635
rs3786075:1422482A/GSLC6A3intron0.8650.983240.01150.14185
rs37972005:1393344T/CSLC6A3untranslated-30.8840.995510.01310.73025
rs3937955:1428514T/GSLC6A3intron0.9871.020920.01270.10273a
rs4036365:1438354A/CSLC6A3intron0.9910.998400.01450.91255
rs412803775:1394476A/GSLC6A3untranslated-30.7420.905200.04640.031955
rs4182655:1426416A/GSLC6A3intron0.9710.980000.01080.060197
rs4204225:1436408T/CSLC6A3intron0.9570.981960.01080.093685
rs4272845:1429187C/GSLC6A3intron0.9871.020410.01270.11155
rs4567745:1432202C/GSLC6A3intron0.9831.019080.01260.13415
rs4586325:1431302A/GSLC6A3intron0.9900.980890.01270.12855
rs4588605:1430933A/TSLC6A3intron0.9901.019590.01270.12585
rs4591415:1432042T/CSLC6A3intron0.9911.019180.01270.1335
rs4609345:1431306A/GSLC6A3intron0.9900.980980.01270.12855
rs4616775:1431992A/CSLC6A3intron0.9910.981180.01270.13285
rs4617535:1431214T/CSLC6A3intron0.9581.018470.01260.14645
rs4620535:1431554T/CSLC6A3intron0.9830.983240.01280.18595
rs4633795:1431164C/GSLC6A3intron0.9901.019490.01270.12695
rs4640495:1423905A/GSLC6A3intron0.9720.979510.01080.054237
rs4651305:1432876A/GSLC6A3intron0.9911.019180.01270.13375
rs4877815:1433931C/GSLC6A3intron0.9840.981570.01270.14285
rs49755475:1435972A/GSLC6A3intron0.8821.018470.01370.18297
rs49756405:1414316T/CSLC6A3intron0.6440.953520.03320.15185
rs49756415:1414523T/GSLC6A3intron0.6251.006120.01600.70155
rs49756465:1433401A/GSLC6A3intron0.9600.983240.01160.14281f
rs589235925:1414612A/CSLC6A3intron0.6231.011360.04140.78485
rs605538225:1414537A/GSLC6A3intron0.6070.974340.02570.31285
rs616965435:1425313T/GSLC6A3intron0.9640.990840.01280.47637
rs623310845:1412605T/CSLC6A3intron0.7610.990940.01410.51785
rs623311125:1424364A/GSLC6A3intron0.9600.991140.01280.48585
rs623311155:1433272A/CSLC6A3intron0.9571.010560.01290.41485
rs6385775:1433831T/CSLC6A3intron0.9840.981770.01270.14755
rs6389645:1433867T/CSLC6A3intron0.9841.018980.01270.13945
rs68696455:1404548T/CSLC6A3intron0.9720.997700.02200.9155
rs68762255:1406036A/CSLC6A3intron0.9391.001300.02340.95565
rs68768905:1393878A/GSLC6A3untranslated-30.8240.988570.01440.42545
rs715950435:1423264A/GSLC6A3intron0.7941.014610.01600.3646
rs727155165:1395574A/GSLC6A3intron0.8641.054010.03380.11995
rs727155175:1396291A/GSLC6A3intron0.7180.980390.04620.66822b
rs727155185:1396763A/CSLC6A3intron0.7051.034480.04740.4745
rs727155195:1397115C/GSLC6A3intron0.7040.966960.04740.47885
rs727155265:1408227A/TSLC6A3intron0.8881.004010.01420.77897
rs727155345:1426267T/GSLC6A3intron0.8941.008330.02430.7317
rs757013565:1430565T/CSLC6A3intron0.7850.983540.03240.60895
rs768396245:1413660T/CSLC6A3intron0.7140.978140.04590.63054
rs81790295:1409985T/CSLC6A3intron0.8820.995210.01430.73615
rs93128655:1435840A/GSLC6A3intron0.9130.989750.01310.43175
rs93128665:1436102A/GSLC6A3intron0.9481.012480.01310.34295
SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*

  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information
ReferenceStudy typeSample size
22196331GWAS177 cases; 436 controls
ReferenceStudy typeSample size
eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04728; Dopaminergic synapse
KEGG pathway annotationhsa05012; Parkinson's disease
KEGG pathway annotationhsa05030; Cocaine addiction
KEGG pathway annotationhsa05031; Amphetamine addiction
KEGG pathway annotationhsa05034; Alcoholism
GO annotation
GO pathway annotationGO:0002020; protease binding
GO pathway annotationGO:0005102; receptor binding
GO pathway annotationGO:0005329; dopamine transmembrane transporter activity
GO pathway annotationGO:0005330; dopamine:sodium symporter activity
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005737; cytoplasm
GO pathway annotationGO:0005886; plasma membrane
GO pathway annotationGO:0005887; integral component of plasma membrane
GO pathway annotationGO:0007268; synaptic transmission
GO pathway annotationGO:0007568; aging
GO pathway annotationGO:0007595; lactation
GO pathway annotationGO:0007608; sensory perception of smell
GO pathway annotationGO:0007626; locomotory behavior
GO pathway annotationGO:0008144; drug binding
GO pathway annotationGO:0008504; monoamine transmembrane transporter activity
GO pathway annotationGO:0009986; cell surface
GO pathway annotationGO:0010039; response to iron ion
GO pathway annotationGO:0015844; monoamine transport
GO pathway annotationGO:0015872; dopamine transport
GO pathway annotationGO:0016021; integral component of membrane
GO pathway annotationGO:0016600; flotillin complex
GO pathway annotationGO:0021984; adenohypophysis development
GO pathway annotationGO:0030424; axon
GO pathway annotationGO:0032403; protein complex binding
GO pathway annotationGO:0035094; response to nicotine
GO pathway annotationGO:0035240; dopamine binding
GO pathway annotationGO:0040018; positive regulation of multicellular organism growth
GO pathway annotationGO:0042053; regulation of dopamine metabolic process
GO pathway annotationGO:0042136; neurotransmitter biosynthetic process
GO pathway annotationGO:0042220; response to cocaine
GO pathway annotationGO:0042416; dopamine biosynthetic process
GO pathway annotationGO:0042420; dopamine catabolic process
GO pathway annotationGO:0042493; response to drug
GO pathway annotationGO:0043025; neuronal cell body
GO pathway annotationGO:0045471; response to ethanol
GO pathway annotationGO:0046872; metal ion binding
GO pathway annotationGO:0047485; protein N-terminus binding
GO pathway annotationGO:0051583; dopamine uptake involved in synaptic transmission
GO pathway annotationGO:0051591; response to cAMP
GO pathway annotationGO:0051721; protein phosphatase 2A binding
GO pathway annotationGO:0055085; transmembrane transport
GO pathway annotationGO:0060134; prepulse inhibition
GO pathway annotationGO:0072488; ammonium transmembrane transport
GO pathway annotationGO:0098793; presynapse
Co-expression Information

There is no gene co-express this gene!

Expression pattern

There is no expression information about these genes!

Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction