PTGIS

Basic Information
Gene SymbolPTGIS
Entrez Id5740
Positionchr20:48120411..48184707
Descriptionprostaglandin I2 (prostacyclin) synthase
Gene typeprotein-coding
SNP Information

SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*
rs11179349320:48178833T/CPTGISintron0.7041.033650.04840.49343a
rs11221975320:48155793T/GPTGISintron0.7440.935570.03490.056355
rs11239242820:48137163A/GPTGISintron0.6261.007430.03110.81167
rs11285303620:48134293T/CPTGISintron0.6190.962420.04270.37075
rs11311079020:48138051T/CPTGISintron0.7051.049380.05130.34725
rs11685319120:48153842A/GPTGISintron0.6311.035210.06080.56882b
rs11693935620:48184560T/GPTGISintron,near-gene-50.8400.952660.02080.019894
rs1169674820:48128139T/CPTGISintron0.9980.942140.01221.134E-66
rs11714020720:48133384T/CPTGISintron0.7500.906920.05640.083177
rs11722240120:48154723T/CPTGISintron0.7190.878450.06510.046667
rs11722662220:48127269T/CPTGISintron0.7551.015520.06520.81364
rs11723457120:48141334A/CPTGISintron0.6840.958490.05390.43087
rs11723813420:48133817A/GPTGISintron0.7461.047180.06600.48485
rs11776919020:48154718A/GPTGISintron0.7401.026030.02320.26747
rs11780058920:48141239T/CPTGISintron0.6731.045820.05860.44476
rs11792795820:48154547T/CPTGISintron0.9290.978440.02320.34856
rs1190663920:48134616T/CPTGISintron0.7441.030970.04970.53927
rs1190852920:48183215A/GPTGISintron,near-gene-50.8730.952850.02150.024655
rs1216526220:48153049A/GPTGISintron0.7251.077130.02590.0041067
rs1262516620:48167203T/GPTGISintron0.9801.017040.02390.47987
rs1303973920:48125015A/GPTGISintron0.9861.063540.01258.459E-74
rs1343338020:48153395A/GPTGISintron0.7720.927470.02630.0041256
rs13961048120:48177341A/GPTGISintron0.6091.016940.06690.802-
rs14150236920:48150969T/CPTGISintron0.7321.059500.06450.3708-
rs14316277320:48142512A/GPTGISintron0.6540.994710.07150.9408-
rs14433234420:48135276A/GPTGISintron0.7511.060560.04950.235-
rs14899238320:48128880A/GPTGISintron0.7420.914750.04120.03044-
rs14949096020:48180360A/GPTGISintron0.6221.120420.06420.07635-
rs14964898520:48176523A/GPTGISintron0.6611.047280.04380.2919-
rs14981103220:48150396A/GPTGISintron0.7670.921640.02690.002403-
rs15066075420:48138359A/GPTGISintron0.7440.943370.06120.3404-
rs15081863820:48164617T/CPTGISintron0.6171.025930.06710.7032-
rs15094468220:48130173T/CPTGISintron0.7271.045090.04280.3026-
rs18475452920:48154848T/CPTGISintron0.6930.909370.06400.1376-
rs3519337120:48126879T/CPTGISintron0.9971.063220.01225.208E-76
rs481096520:48154079A/GPTGISintron0.8720.974140.01800.14587
rs49149020:48175678A/GPTGISintron0.8100.997700.01260.85855
rs49219520:48120999A/CPTGISuntranslated-30.9961.057070.01172.279E-66
rs49369420:48183130T/CPTGISintron,near-gene-50.8700.989260.01130.34125
rs49514620:48130328T/CPTGISintron0.9941.064280.01202.128E-72b
rs49696220:48136724T/CPTGISintron0.8330.942900.01530.00012117
rs49706920:48136682T/CPTGISintron0.8220.946110.01500.00021765
rs50497420:48152343A/GPTGISintron0.9261.020300.02310.38257
rs50875720:48138971T/CPTGISintron0.9161.055270.01420.00014466
rs51107320:48182021A/GPTGISintron0.9100.979710.01510.17456
rs51563320:48163144A/GPTGISintron0.9591.014610.02340.53576
rs52296220:48143362T/CPTGISintron0.9441.008030.01100.46435
rs6016966820:48132571A/CPTGISintron0.8050.943180.06840.39255
rs601987920:48130628T/CPTGISintron0.9930.938100.01211.388E-76
rs601990220:48178213A/GPTGISintron0.8650.976580.01480.10797
rs609099620:48133782A/GPTGISintron0.8960.947240.01430.00014595
rs609099720:48142132A/TPTGISintron0.8971.012780.02180.55866
rs609099820:48142133A/TPTGISintron0.8501.011260.02200.60946
rs609100020:48152675T/CPTGISintron0.7721.077990.02620.0041936
rs6101312720:48133549A/GPTGISintron0.7711.046870.01430.0013396
rs6132288420:48156249A/GPTGIScoding-synon0.6620.974820.03960.51897
rs6220922220:48160782T/CPTGISintron0.6370.970250.06960.66445
rs6220922420:48177154T/CPTGISintron0.6120.996610.03810.92967
rs6651590620:48177868A/GPTGISintron0.7900.989460.01630.51777
rs70752920:48181035A/GPTGISintron0.8021.006620.01190.57967
rs726734820:48131036T/CPTGISintron0.9930.937820.01211.182E-75
rs727324720:48170236T/CPTGISintron0.7721.089700.05690.13117
rs72982420:48127176T/CPTGISintron0.9970.940820.01225.938E-72b
rs7312417320:48139768A/CPTGISintron0.7910.898080.04510.017217
rs7312417720:48156373A/GPTGISintron0.7351.025320.02320.28266
rs7312417920:48162539A/GPTGISintron0.7211.030970.02230.1716
rs7312419220:48177403A/GPTGISintron0.7440.968890.02540.2145
rs7312622120:48184048A/GPTGISintron,near-gene-50.7830.955140.03320.16695
rs7541647220:48176141T/CPTGISintron0.6611.021530.03050.48615
rs7699899120:48147756T/CPTGISintron0.6850.985800.03850.70976
rs7731787420:48132398T/CPTGISintron0.8120.935570.04030.097842b
rs7740127520:48134818A/GPTGISintron0.6660.976580.04160.56897
rs7782327320:48136683A/GPTGISintron0.7091.038630.04970.4465
rs7813437520:48127380T/CPTGISintron0.7290.956280.04290.2974
rs7886580920:48183370T/CPTGISintron,near-gene-50.7660.965510.03710.34375
rs8003136820:48154367A/GPTGISintron0.7010.967150.04450.45257
rs811530520:48147421T/CPTGISintron0.6821.077560.04220.076387
rs812174920:48128589A/GPTGISintron0.9960.941010.01225.707E-76
rs92706820:48177974T/GPTGISintron0.8740.965120.01320.0072575
rs96345520:48179993T/CPTGISintron0.8631.023880.01220.053244
SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*

  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa00590; Arachidonic acid metabolism
KEGG pathway annotationhsa01100; Metabolic pathways
GO annotation
GO pathway annotationGO:0001516; prostaglandin biosynthetic process
GO pathway annotationGO:0004497; monooxygenase activity
GO pathway annotationGO:0005506; iron ion binding
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005615; extracellular space
GO pathway annotationGO:0005634; nucleus
GO pathway annotationGO:0005783; endoplasmic reticulum
GO pathway annotationGO:0005789; endoplasmic reticulum membrane
GO pathway annotationGO:0005901; caveola
GO pathway annotationGO:0006690; icosanoid metabolic process
GO pathway annotationGO:0006766; vitamin metabolic process
GO pathway annotationGO:0006767; water-soluble vitamin metabolic process
GO pathway annotationGO:0006769; nicotinamide metabolic process
GO pathway annotationGO:0006805; xenobiotic metabolic process
GO pathway annotationGO:0007566; embryo implantation
GO pathway annotationGO:0008116; prostaglandin-I synthase activity
GO pathway annotationGO:0016021; integral component of membrane
GO pathway annotationGO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO pathway annotationGO:0019369; arachidonic acid metabolic process
GO pathway annotationGO:0019371; cyclooxygenase pathway
GO pathway annotationGO:0019674; NAD metabolic process
GO pathway annotationGO:0020037; heme binding
GO pathway annotationGO:0032088; negative regulation of NF-kappaB transcription factor activity
GO pathway annotationGO:0035360; positive regulation of peroxisome proliferator activated receptor signaling pathway
GO pathway annotationGO:0044281; small molecule metabolic process
GO pathway annotationGO:0045019; negative regulation of nitric oxide biosynthetic process
GO pathway annotationGO:0045766; positive regulation of angiogenesis
GO pathway annotationGO:0046697; decidualization
GO pathway annotationGO:0050728; negative regulation of inflammatory response
GO pathway annotationGO:0055114; oxidation-reduction process
GO pathway annotationGO:0071347; cellular response to interleukin-1
GO pathway annotationGO:0071354; cellular response to interleukin-6
GO pathway annotationGO:0071456; cellular response to hypoxia
GO pathway annotationGO:0097190; apoptotic signaling pathway
GO pathway annotationGO:1900119; positive regulation of execution phase of apoptosis
Co-expression Information

There is no gene co-express this gene!

Expression pattern
Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction

There is no PPI information about this gene in InWeb