PROC

Basic Information
Gene SymbolPROC
Entrez Id5624
Positionchr2:128175996..128186822
Descriptionprotein C (inactivator of coagulation factors Va and VIIIa)
Gene typeprotein-coding
SNP Information

SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*
rs1389351912:128184210T/CPROCintron0.7371.005520.05620.9219-
rs1433251862:128174424A/GPROCnear-gene-50.8580.987080.05470.8115-
rs15187592:128182375T/GPROCintron,near-gene-50.9881.003410.01140.76765
rs17998082:128175862T/CPROCnear-gene-50.9760.994710.01110.63574
rs17998092:128175875A/GPROCnear-gene-50.9830.996210.01080.72674
rs17998102:128176040A/TPROCcoding-synon,near-gene-5,untranslated-50.9830.995410.01080.67234
rs1816268942:128184596A/GPROCintron0.9600.958870.05310.4287-
rs20698952:128174068A/GPROCnear-gene-50.9770.998100.01160.86892b
rs20698982:128174227T/CPROCnear-gene-50.9840.996410.01160.75462b
rs20699012:128174843T/CPROCnear-gene-50.9800.994220.01090.59485
rs20699022:128174863C/GPROCnear-gene-50.9860.996210.01160.74535
rs20699042:128175779A/GPROCnear-gene-50.9881.003210.01160.77955
rs20699062:128176677A/GPROCintron,missense0.9681.023680.02600.36844
rs20699072:128176706A/GPROCintron0.9690.990350.02490.6974
rs20699102:128177974T/CPROCintron0.9750.995410.01080.66835
rs20699122:128178191T/CPROCintron0.9810.994120.01210.62462b
rs20699132:128178259C/GPROCintron0.9800.997700.01280.85952b
rs20699142:128178272A/GPROCintron0.9811.005920.01210.62644
rs20699152:128178378A/GPROCintron0.9740.992330.01080.4795
rs20699162:128178415T/CPROCintron0.9740.990050.01120.36825
rs20699182:128179326A/GPROCintron0.9811.003410.01280.78775
rs20699192:128179553A/GPROCintron0.9871.003710.01160.74665
rs20699202:128179646T/CPROCintron0.9731.007530.01080.48694
rs20699212:128179838A/GPROCintron0.9830.994320.01200.6364
rs20699232:128182658A/CPROCintron,near-gene-50.9740.982160.02610.49063a
rs20699242:128182994T/CPROCintron,near-gene-50.9810.992830.01110.51342b
rs20699282:128183914T/GPROCintron0.9801.007730.01340.56767
rs20699312:128185569T/CPROCintron0.9850.991930.01100.46297
rs20699332:128185688T/CPROCintron0.9921.004010.01140.72546
rs20699382:128181399T/CPROCintron,near-gene-50.8101.037170.03130.24414
rs20699392:128183145T/CPROCintron,near-gene-50.9701.008640.02480.72995
rs412805702:128176230T/CPROCintron,near-gene-50.9741.003610.01160.75562b
rs59372:128184770T/CPROCcoding-synon0.9950.995410.01150.68894
SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*

  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04610; Complement and coagulation cascades
GO annotation
GO pathway annotationGO:0004252; serine-type endopeptidase activity
GO pathway annotationGO:0005509; calcium ion binding
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005576; extracellular region
GO pathway annotationGO:0005615; extracellular space
GO pathway annotationGO:0005783; endoplasmic reticulum
GO pathway annotationGO:0005788; endoplasmic reticulum lumen
GO pathway annotationGO:0005794; Golgi apparatus
GO pathway annotationGO:0005796; Golgi lumen
GO pathway annotationGO:0006465; signal peptide processing
GO pathway annotationGO:0006508; proteolysis
GO pathway annotationGO:0006888; ER to Golgi vesicle-mediated transport
GO pathway annotationGO:0007596; blood coagulation
GO pathway annotationGO:0017187; peptidyl-glutamic acid carboxylation
GO pathway annotationGO:0030195; negative regulation of blood coagulation
GO pathway annotationGO:0043066; negative regulation of apoptotic process
GO pathway annotationGO:0043687; post-translational protein modification
GO pathway annotationGO:0044267; cellular protein metabolic process
GO pathway annotationGO:0050728; negative regulation of inflammatory response
GO pathway annotationGO:0050819; negative regulation of coagulation
GO pathway annotationGO:0050900; leukocyte migration
GO pathway annotationGO:1903142; positive regulation of establishment of endothelial barrier
Co-expression Information

There is no gene co-express this gene!

Expression pattern
Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction