Basic Information
Gene SymbolIL4
Entrez Id3565
Descriptioninterleukin 4
Gene typeprotein-coding
SNP Information


  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04060; Cytokine-cytokine receptor interaction
KEGG pathway annotationhsa04151; PI3K-Akt signaling pathway
KEGG pathway annotationhsa04630; Jak-STAT signaling pathway
KEGG pathway annotationhsa04640; Hematopoietic cell lineage
KEGG pathway annotationhsa04660; T cell receptor signaling pathway
KEGG pathway annotationhsa04664; Fc epsilon RI signaling pathway
KEGG pathway annotationhsa04672; Intestinal immune network for IgA production
KEGG pathway annotationhsa05140; Leishmaniasis
KEGG pathway annotationhsa05162; Measles
KEGG pathway annotationhsa05310; Asthma
KEGG pathway annotationhsa05320; Autoimmune thyroid disease
KEGG pathway annotationhsa05321; Inflammatory bowel disease (IBD)
KEGG pathway annotationhsa05330; Allograft rejection
GO annotation
GO pathway annotationGO:0001774; microglial cell activation
GO pathway annotationGO:0002227; innate immune response in mucosa
GO pathway annotationGO:0002230; positive regulation of defense response to virus by host
GO pathway annotationGO:0002296; T-helper 1 cell lineage commitment
GO pathway annotationGO:0002674; negative regulation of acute inflammatory response
GO pathway annotationGO:0002677; negative regulation of chronic inflammatory response
GO pathway annotationGO:0005125; cytokine activity
GO pathway annotationGO:0005136; interleukin-4 receptor binding
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005615; extracellular space
GO pathway annotationGO:0006935; chemotaxis
GO pathway annotationGO:0006955; immune response
GO pathway annotationGO:0006968; cellular defense response
GO pathway annotationGO:0007565; female pregnancy
GO pathway annotationGO:0007584; response to nutrient
GO pathway annotationGO:0008083; growth factor activity
GO pathway annotationGO:0008203; cholesterol metabolic process
GO pathway annotationGO:0009897; external side of plasma membrane
GO pathway annotationGO:0010155; regulation of proton transport
GO pathway annotationGO:0010633; negative regulation of epithelial cell migration
GO pathway annotationGO:0014070; response to organic cyclic compound
GO pathway annotationGO:0030183; B cell differentiation
GO pathway annotationGO:0030890; positive regulation of B cell proliferation
GO pathway annotationGO:0031296; B cell costimulation
GO pathway annotationGO:0032733; positive regulation of interleukin-10 production
GO pathway annotationGO:0032736; positive regulation of interleukin-13 production
GO pathway annotationGO:0034097; response to cytokine
GO pathway annotationGO:0035745; T-helper 2 cell cytokine production
GO pathway annotationGO:0042092; type 2 immune response
GO pathway annotationGO:0042102; positive regulation of T cell proliferation
GO pathway annotationGO:0042104; positive regulation of activated T cell proliferation
GO pathway annotationGO:0042325; regulation of phosphorylation
GO pathway annotationGO:0042493; response to drug
GO pathway annotationGO:0042523; positive regulation of tyrosine phosphorylation of Stat5 protein
GO pathway annotationGO:0042832; defense response to protozoan
GO pathway annotationGO:0043011; myeloid dendritic cell differentiation
GO pathway annotationGO:0043031; negative regulation of macrophage activation
GO pathway annotationGO:0043066; negative regulation of apoptotic process
GO pathway annotationGO:0043306; positive regulation of mast cell degranulation
GO pathway annotationGO:0045019; negative regulation of nitric oxide biosynthetic process
GO pathway annotationGO:0045064; T-helper 2 cell differentiation
GO pathway annotationGO:0045080; positive regulation of chemokine biosynthetic process
GO pathway annotationGO:0045189; connective tissue growth factor biosynthetic process
GO pathway annotationGO:0045191; regulation of isotype switching
GO pathway annotationGO:0045348; positive regulation of MHC class II biosynthetic process
GO pathway annotationGO:0045471; response to ethanol
GO pathway annotationGO:0045582; positive regulation of T cell differentiation
GO pathway annotationGO:0045671; negative regulation of osteoclast differentiation
GO pathway annotationGO:0045892; negative regulation of transcription, DNA-templated
GO pathway annotationGO:0045893; positive regulation of transcription, DNA-templated
GO pathway annotationGO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO pathway annotationGO:0048295; positive regulation of isotype switching to IgE isotypes
GO pathway annotationGO:0048304; positive regulation of isotype switching to IgG isotypes
GO pathway annotationGO:0050776; regulation of immune response
GO pathway annotationGO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO pathway annotationGO:0060041; retina development in camera-type eye
GO pathway annotationGO:0070351; negative regulation of white fat cell proliferation
GO pathway annotationGO:0071288; cellular response to mercury ion
GO pathway annotationGO:0071677; positive regulation of mononuclear cell migration
GO pathway annotationGO:0097028; dendritic cell differentiation
GO pathway annotationGO:0097192; extrinsic apoptotic signaling pathway in absence of ligand
GO pathway annotationGO:1901741; positive regulation of myoblast fusion
GO pathway annotationGO:1903660; negative regulation of complement-dependent cytotoxicity
GO pathway annotationGO:2000320; negative regulation of T-helper 17 cell differentiation
GO pathway annotationGO:2000352; negative regulation of endothelial cell apoptotic process
GO pathway annotationGO:2000424; positive regulation of eosinophil chemotaxis
GO pathway annotationGO:2001237; negative regulation of extrinsic apoptotic signaling pathway
Co-expression Information

There is no gene co-express this gene!

Expression pattern

There is no expression information about these genes!

Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction