IL12B

Basic Information
Gene SymbolIL12B
Entrez Id3593
Positionchr5:158741791..158757481
Descriptioninterleukin 12B
Gene typeprotein-coding
SNP Information

There is no SZ(PGC) snp in this gene!

CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04060; Cytokine-cytokine receptor interaction
KEGG pathway annotationhsa04620; Toll-like receptor signaling pathway
KEGG pathway annotationhsa04622; RIG-I-like receptor signaling pathway
KEGG pathway annotationhsa04630; Jak-STAT signaling pathway
KEGG pathway annotationhsa04940; Type I diabetes mellitus
KEGG pathway annotationhsa05133; Pertussis
KEGG pathway annotationhsa05134; Legionellosis
KEGG pathway annotationhsa05140; Leishmaniasis
KEGG pathway annotationhsa05142; Chagas disease (American trypanosomiasis)
KEGG pathway annotationhsa05143; African trypanosomiasis
KEGG pathway annotationhsa05145; Toxoplasmosis
KEGG pathway annotationhsa05146; Amoebiasis
KEGG pathway annotationhsa05152; Tuberculosis
KEGG pathway annotationhsa05162; Measles
KEGG pathway annotationhsa05164; Influenza A
KEGG pathway annotationhsa05168; Herpes simplex infection
KEGG pathway annotationhsa05205; Proteoglycans in cancer
KEGG pathway annotationhsa05321; Inflammatory bowel disease (IBD)
KEGG pathway annotationhsa05330; Allograft rejection
GO annotation
GO pathway annotationGO:0001916; positive regulation of T cell mediated cytotoxicity
GO pathway annotationGO:0002230; positive regulation of defense response to virus by host
GO pathway annotationGO:0002323; natural killer cell activation involved in immune response
GO pathway annotationGO:0002827; positive regulation of T-helper 1 type immune response
GO pathway annotationGO:0002860; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO pathway annotationGO:0002862; negative regulation of inflammatory response to antigenic stimulus
GO pathway annotationGO:0004896; cytokine receptor activity
GO pathway annotationGO:0005125; cytokine activity
GO pathway annotationGO:0005143; interleukin-12 receptor binding
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005615; extracellular space
GO pathway annotationGO:0005737; cytoplasm
GO pathway annotationGO:0007050; cell cycle arrest
GO pathway annotationGO:0008083; growth factor activity
GO pathway annotationGO:0010224; response to UV-B
GO pathway annotationGO:0010535; positive regulation of activation of JAK2 kinase activity
GO pathway annotationGO:0016020; membrane
GO pathway annotationGO:0016477; cell migration
GO pathway annotationGO:0019221; cytokine-mediated signaling pathway
GO pathway annotationGO:0019233; sensory perception of pain
GO pathway annotationGO:0019953; sexual reproduction
GO pathway annotationGO:0030101; natural killer cell activation
GO pathway annotationGO:0032693; negative regulation of interleukin-10 production
GO pathway annotationGO:0032700; negative regulation of interleukin-17 production
GO pathway annotationGO:0032725; positive regulation of granulocyte macrophage colony-stimulating factor production
GO pathway annotationGO:0032729; positive regulation of interferon-gamma production
GO pathway annotationGO:0032733; positive regulation of interleukin-10 production
GO pathway annotationGO:0032735; positive regulation of interleukin-12 production
GO pathway annotationGO:0032740; positive regulation of interleukin-17 production
GO pathway annotationGO:0032760; positive regulation of tumor necrosis factor production
GO pathway annotationGO:0032816; positive regulation of natural killer cell activation
GO pathway annotationGO:0032819; positive regulation of natural killer cell proliferation
GO pathway annotationGO:0032946; positive regulation of mononuclear cell proliferation
GO pathway annotationGO:0034105; positive regulation of tissue remodeling
GO pathway annotationGO:0034393; positive regulation of smooth muscle cell apoptotic process
GO pathway annotationGO:0042035; regulation of cytokine biosynthetic process
GO pathway annotationGO:0042088; T-helper 1 type immune response
GO pathway annotationGO:0042093; T-helper cell differentiation
GO pathway annotationGO:0042095; interferon-gamma biosynthetic process
GO pathway annotationGO:0042102; positive regulation of T cell proliferation
GO pathway annotationGO:0042104; positive regulation of activated T cell proliferation
GO pathway annotationGO:0042164; interleukin-12 alpha subunit binding
GO pathway annotationGO:0042346; positive regulation of NF-kappaB import into nucleus
GO pathway annotationGO:0042510; regulation of tyrosine phosphorylation of Stat1 protein
GO pathway annotationGO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO pathway annotationGO:0042520; positive regulation of tyrosine phosphorylation of Stat4 protein
GO pathway annotationGO:0042523; positive regulation of tyrosine phosphorylation of Stat5 protein
GO pathway annotationGO:0042802; identical protein binding
GO pathway annotationGO:0042803; protein homodimerization activity
GO pathway annotationGO:0042832; defense response to protozoan
GO pathway annotationGO:0043382; positive regulation of memory T cell differentiation
GO pathway annotationGO:0043514; interleukin-12 complex
GO pathway annotationGO:0044130; negative regulation of growth of symbiont in host
GO pathway annotationGO:0045078; positive regulation of interferon-gamma biosynthetic process
GO pathway annotationGO:0045519; interleukin-23 receptor binding
GO pathway annotationGO:0045672; positive regulation of osteoclast differentiation
GO pathway annotationGO:0045785; positive regulation of cell adhesion
GO pathway annotationGO:0046982; protein heterodimerization activity
GO pathway annotationGO:0048662; negative regulation of smooth muscle cell proliferation
GO pathway annotationGO:0050671; positive regulation of lymphocyte proliferation
GO pathway annotationGO:0050729; positive regulation of inflammatory response
GO pathway annotationGO:0050829; defense response to Gram-negative bacterium
GO pathway annotationGO:0051135; positive regulation of NK T cell activation
GO pathway annotationGO:0051142; positive regulation of NK T cell proliferation
GO pathway annotationGO:0051607; defense response to virus
GO pathway annotationGO:0070743; interleukin-23 complex
GO pathway annotationGO:0071222; cellular response to lipopolysaccharide
GO pathway annotationGO:0071346; cellular response to interferon-gamma
GO pathway annotationGO:2000318; positive regulation of T-helper 17 type immune response
GO pathway annotationGO:2000330; positive regulation of T-helper 17 cell lineage commitment
Co-expression Information

There is no gene co-express this gene!

Expression pattern
Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction

There is no PPI information about this gene in InWeb