F2

Basic Information
Gene SymbolF2
Entrez Id2147
Positionchr11:46740743..46761056
Descriptioncoagulation factor II (thrombin)
Gene typeprotein-coding
SNP Information

SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*
rs11320254911:46741020T/GF2intron0.9711.124120.05730.041134
rs11328002011:46753469T/GF2intron0.9780.942330.02070.0041176
rs11642952411:46759284A/GF2intron0.9771.121760.05710.044176
rs14006749311:46755441T/CF2intron0.6610.984420.04030.6968-
rs179986711:46747979T/CF2intron0.9941.034380.01500.024494
rs179996311:46761055A/GF2near-gene-3,untranslated-30.8340.986890.05870.82197
rs18576430311:46756234A/GF2intron0.6470.946860.05410.3127-
rs18748193611:46757206T/CF2intron0.7421.028810.04800.5534-
rs207085011:46741495T/CF2intron0.9810.966470.01520.024994
rs207085111:46744528T/CF2intron0.9960.987280.01250.30395
rs207085211:46744925C/GF2intron1.0000.963290.01140.0010395
rs228268611:46750638T/CF2intron0.9880.962710.01150.00090767
rs313643311:46741908A/CF2intron0.9951.086540.01900.000012377
rs313643411:46742249T/CF2intron0.9950.920350.01900.000012372b
rs313643511:46742426A/GF2intron0.9961.070040.02040.00091512b
rs313643611:46742489A/GF2intron0.9950.920350.01900.000012397
rs313643911:46743135T/CF2intron0.9980.920720.01890.000012831f
rs313644111:46743247T/CF2intron0.9981.033450.01500.028165
rs313644311:46743334T/CF2intron0.9950.920350.01900.00001256
rs313644611:46744357A/GF2intron0.9951.086540.01900.000012345
rs313644711:46744368T/CF2intron0.9950.986590.01250.28135
rs313644811:46744369A/GF2intron0.9961.086650.01900.000011865
rs313644911:46744470A/GF2intron0.9980.967730.01500.028835
rs313645611:46745861A/CF2intron0.9971.063640.02050.0026055
rs313645711:46746258C/GF2intron0.9970.967350.01500.02717
rs313645811:46746616A/GF2intron0.9820.965030.01510.018546
rs313646011:46747065C/GF2intron0.9961.033960.01500.026095
rs313646711:46749234A/GF2intron0.9941.087090.01900.000011115
rs313646811:46749246T/CF2intron0.9940.919890.01900.00001125
rs313646911:46749334A/TF2intron0.9941.087090.01900.000011146
rs313647211:46750064C/GF2intron0.9940.919800.01900.000010955
rs313647411:46750819T/CF2intron0.9880.940450.02050.00275
rs313648011:46751848T/GF2intron0.9930.919620.01900.000010475
rs313648111:46752659T/GF2intron0.9931.087410.01900.000010347
rs313648211:46752958T/CF2intron0.9930.919520.01900.000010286
rs313648711:46755464A/GF2intron0.9470.917690.01906.1E-65
rs313648911:46755653A/TF2intron0.9931.087630.01909.917E-65
rs313649011:46755794T/CF2intron0.9711.065670.02040.0018156
rs313649611:46758037A/GF2intron0.9921.087520.01900.000010357
rs313649911:46758290A/GF2intron0.9890.962910.01510.012544
rs313650011:46758383T/CF2intron0.9921.087740.01909.906E-64
rs313650411:46758882T/CF2intron0.9921.087740.01909.713E-67
rs313650511:46759571A/GF2intron0.9640.971610.01170.013777
rs313650811:46759709T/CF2intron0.8071.037800.02380.11886
rs313651211:46760120T/CF2intron0.9600.986000.01080.19287
rs313651611:46760756A/GF2intron0.9770.973170.01080.011754
rs313652011:46743232T/CF2intron0.9261.030350.03290.36391f
rs313652111:46743432A/GF2intron0.9961.086540.01900.00001237
rs313652411:46750525A/GF2intron0.8421.042580.04310.33326
rs6188430711:46755388C/GF2intron0.9561.088720.01833.635E-65
rs7518585311:46751401T/CF2intron0.9901.036340.01510.018175
rs7948747711:46751184A/GF2intron0.7250.981280.06640.7764
rs979494111:46738761A/GF2near-gene-50.9701.124680.05730.040267
SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*

  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04080; Neuroactive ligand-receptor interaction
KEGG pathway annotationhsa04610; Complement and coagulation cascades
KEGG pathway annotationhsa04810; Regulation of actin cytoskeleton
GO annotation
GO pathway annotationGO:0001934; positive regulation of protein phosphorylation
GO pathway annotationGO:0004252; serine-type endopeptidase activity
GO pathway annotationGO:0005102; receptor binding
GO pathway annotationGO:0005509; calcium ion binding
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005576; extracellular region
GO pathway annotationGO:0005615; extracellular space
GO pathway annotationGO:0005788; endoplasmic reticulum lumen
GO pathway annotationGO:0005796; Golgi lumen
GO pathway annotationGO:0005829; cytosol
GO pathway annotationGO:0005886; plasma membrane
GO pathway annotationGO:0006465; signal peptide processing
GO pathway annotationGO:0006508; proteolysis
GO pathway annotationGO:0006888; ER to Golgi vesicle-mediated transport
GO pathway annotationGO:0006953; acute-phase response
GO pathway annotationGO:0007166; cell surface receptor signaling pathway
GO pathway annotationGO:0007275; multicellular organismal development
GO pathway annotationGO:0007596; blood coagulation
GO pathway annotationGO:0007597; blood coagulation, intrinsic pathway
GO pathway annotationGO:0008083; growth factor activity
GO pathway annotationGO:0008284; positive regulation of cell proliferation
GO pathway annotationGO:0008360; regulation of cell shape
GO pathway annotationGO:0009611; response to wounding
GO pathway annotationGO:0010468; regulation of gene expression
GO pathway annotationGO:0010544; negative regulation of platelet activation
GO pathway annotationGO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO pathway annotationGO:0014854; response to inactivity
GO pathway annotationGO:0017187; peptidyl-glutamic acid carboxylation
GO pathway annotationGO:0030168; platelet activation
GO pathway annotationGO:0030193; regulation of blood coagulation
GO pathway annotationGO:0030194; positive regulation of blood coagulation
GO pathway annotationGO:0030307; positive regulation of cell growth
GO pathway annotationGO:0031012; extracellular matrix
GO pathway annotationGO:0032967; positive regulation of collagen biosynthetic process
GO pathway annotationGO:0042730; fibrinolysis
GO pathway annotationGO:0043687; post-translational protein modification
GO pathway annotationGO:0044267; cellular protein metabolic process
GO pathway annotationGO:0045861; negative regulation of proteolysis
GO pathway annotationGO:0048712; negative regulation of astrocyte differentiation
GO pathway annotationGO:0050900; leukocyte migration
GO pathway annotationGO:0051281; positive regulation of release of sequestered calcium ion into cytosol
GO pathway annotationGO:0051480; cytosolic calcium ion homeostasis
GO pathway annotationGO:0051918; negative regulation of fibrinolysis
GO pathway annotationGO:0070053; thrombospondin receptor activity
GO pathway annotationGO:0070062; extracellular exosome
GO pathway annotationGO:0071260; cellular response to mechanical stimulus
GO pathway annotationGO:0072562; blood microparticle
GO pathway annotationGO:1900738; positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
GO pathway annotationGO:2000379; positive regulation of reactive oxygen species metabolic process
Co-expression Information

There is no gene co-express this gene!

Expression pattern

There is no expression information about these genes!

Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction