CXCR2

Basic Information
Gene SymbolCXCR2
Entrez Id3579
Positionchr2:218990013..219001976
Descriptionchemokine (C-X-C motif) receptor 2
Gene typeprotein-coding
SNP Information

SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*
rs1129989232:218988539T/CCXCR2near-gene-50.9981.044770.02970.14026
rs1136025042:218994403T/CCXCR2intron,near-gene-50.9931.044360.02620.097195
rs133064412:219000945A/GCXCR2untranslated-30.9990.956280.02980.13366
rs178446822:218994942A/GCXCR2intron,near-gene-50.9900.996010.02490.87386
rs178446972:218999255A/GCXCR2intron0.9950.994520.01070.60987
rs178447612:218998053T/CCXCR2intron0.6931.053380.04270.22327
rs22300542:219000310T/CCXCR2coding-synon0.9840.995810.01070.69057
rs46728722:218988061A/GCXCR2near-gene-50.9871.001600.01060.88426
rs46742572:218988774A/GCXCR2near-gene-50.9960.998000.01060.84855
rs46742582:218990586T/CCXCR2intron,near-gene-50.9930.994420.01060.59495
rs46742592:218991005A/GCXCR2intron,untranslated-50.9961.003210.01060.76331f
rs46742602:219002376T/CCXCR2near-gene-30.9960.997900.01060.84485
rs67234492:218997580T/CCXCR2intron0.9960.998700.01060.90546
SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*

  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04060; Cytokine-cytokine receptor interaction
KEGG pathway annotationhsa04062; Chemokine signaling pathway
KEGG pathway annotationhsa04144; Endocytosis
KEGG pathway annotationhsa05120; Epithelial cell signaling in Helicobacter pylori infection
GO annotation
GO pathway annotationGO:0002407; dendritic cell chemotaxis
GO pathway annotationGO:0002438; acute inflammatory response to antigenic stimulus
GO pathway annotationGO:0004871; signal transducer activity
GO pathway annotationGO:0004918; interleukin-8 receptor activity
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005622; intracellular
GO pathway annotationGO:0005829; cytosol
GO pathway annotationGO:0005886; plasma membrane
GO pathway annotationGO:0005887; integral component of plasma membrane
GO pathway annotationGO:0006935; chemotaxis
GO pathway annotationGO:0006954; inflammatory response
GO pathway annotationGO:0006968; cellular defense response
GO pathway annotationGO:0007165; signal transduction
GO pathway annotationGO:0007166; cell surface receptor signaling pathway
GO pathway annotationGO:0007200; phospholipase C-activating G-protein coupled receptor signaling pathway
GO pathway annotationGO:0007204; positive regulation of cytosolic calcium ion concentration
GO pathway annotationGO:0008284; positive regulation of cell proliferation
GO pathway annotationGO:0009986; cell surface
GO pathway annotationGO:0010666; positive regulation of cardiac muscle cell apoptotic process
GO pathway annotationGO:0016020; membrane
GO pathway annotationGO:0016494; C-X-C chemokine receptor activity
GO pathway annotationGO:0019959; interleukin-8 binding
GO pathway annotationGO:0030593; neutrophil chemotaxis
GO pathway annotationGO:0030901; midbrain development
GO pathway annotationGO:0031623; receptor internalization
GO pathway annotationGO:0033030; negative regulation of neutrophil apoptotic process
GO pathway annotationGO:0038112; interleukin-8-mediated signaling pathway
GO pathway annotationGO:0042119; neutrophil activation
GO pathway annotationGO:0042629; mast cell granule
GO pathway annotationGO:0043117; positive regulation of vascular permeability
GO pathway annotationGO:0045766; positive regulation of angiogenesis
GO pathway annotationGO:0070098; chemokine-mediated signaling pathway
GO pathway annotationGO:0072173; metanephric tubule morphogenesis
GO pathway annotationGO:0090023; positive regulation of neutrophil chemotaxis
Co-expression Information

There is no gene co-express this gene!

Expression pattern
Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction