CHRNB4

Basic Information
Gene SymbolCHRNB4
Entrez Id1143
Positionchr15:78916636..78933587
Descriptioncholinergic receptor, nicotinic, beta 4 (neuronal)
Gene typeprotein-coding
SNP Information

SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*
rs1107276815:78929478T/GCHRNB4intron0.9830.933510.01321.707E-75
rs11350335215:78917981T/CCHRNB4intron0.9050.986990.04920.79045
rs1244001415:78926726C/GCHRNB4intron0.9371.077130.01285.527E-95
rs1244029815:78927589T/GCHRNB4intron0.7601.041640.04110.32145
rs1244108815:78928264T/GCHRNB4intron0.8691.057920.01279.392E-67
rs1244199815:78929372A/GCHRNB4intron0.9831.070370.01322.345E-75
rs1259395015:78920935C/GCHRNB4intron0.9580.923760.01285.848E-105
rs1291400815:78923505A/GCHRNB4missense0.9701.029220.02800.30365
rs131697115:78930510A/GCHRNB4intron0.9840.934820.01322.961E-75
rs13886850415:78931734A/GCHRNB4intron0.7170.950470.06200.4127-
rs14120860215:78931463T/GCHRNB4intron0.7090.942140.03160.05933-
rs14783607615:78924600T/GCHRNB4intron0.8590.992330.01210.5279-
rs1748722315:78923987T/CCHRNB4intron0.9671.056540.01131.222E-65
rs18789181315:78934793A/CCHRNB4near-gene-50.6400.926540.06810.2625-
rs19175628515:78924534T/GCHRNB4intron0.6571.044150.04180.3019-
rs2853457515:78923845T/GCHRNB4intron0.9541.083610.01283.819E-105
rs2854443215:78924538T/GCHRNB4intron0.7531.061940.01590.00016276
rs290413015:78916622C/GCHRNB4near-gene-30.9771.010350.01120.35795
rs3604586915:78929498T/CCHRNB4intron0.9621.006620.01110.55485
rs381356715:78934551A/GCHRNB4near-gene-50.9511.071440.01321.867E-75
rs488707215:78925435A/GCHRNB4intron0.9491.081990.01298.575E-105
rs6201033715:78924542T/GCHRNB4intron0.6300.971710.01350.033576
rs649530915:78915245T/CCHRNB4near-gene-50.9790.922840.01272.945E-105
rs6717587615:78928399A/GCHRNB4intron0.9411.070370.01322.361E-77
rs6742632815:78934318C/GCHRNB4near-gene-50.9580.951420.01130.000010165
rs7152852615:78923092T/CCHRNB4intron0.8960.997000.04920.95085
rs717827015:78921077C/GCHRNB4intron0.9680.990050.01090.3575
rs7264890215:78934148A/TCHRNB4near-gene-50.6350.869360.05520.011225
rs7274315715:78926250A/GCHRNB4intron0.7270.878710.04780.0068635
rs7274315815:78926445T/CCHRNB4intron0.9530.947620.01142.3E-65
rs7274316815:78935235T/CCHRNB4near-gene-50.6661.001900.02620.94084
rs7780241115:78925414T/CCHRNB4intron0.7100.942420.03170.061775
rs7960928415:78928411A/GCHRNB4intron0.9291.009650.01170.41177
rs803944915:78914534T/CCHRNB4near-gene-50.9791.051170.01117.615E-65
rs95077615:78926018T/CCHRNB4intron0.9850.988760.01130.31871f
rs992050615:78931057A/GCHRNB4intron0.8560.937630.01447.968E-64
SNPPositionAlelleGeneAnnotationInfoOrSeP-valueeQTLScore*

  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04080; Neuroactive ligand-receptor interaction
KEGG pathway annotationhsa04725; Cholinergic synapse
GO annotation
GO pathway annotationGO:0001508; action potential
GO pathway annotationGO:0004889; acetylcholine-activated cation-selective channel activity
GO pathway annotationGO:0005886; plasma membrane
GO pathway annotationGO:0005887; integral component of plasma membrane
GO pathway annotationGO:0005892; acetylcholine-gated channel complex
GO pathway annotationGO:0006811; ion transport
GO pathway annotationGO:0006939; smooth muscle contraction
GO pathway annotationGO:0006940; regulation of smooth muscle contraction
GO pathway annotationGO:0007165; signal transduction
GO pathway annotationGO:0007268; synaptic transmission
GO pathway annotationGO:0007271; synaptic transmission, cholinergic
GO pathway annotationGO:0007626; locomotory behavior
GO pathway annotationGO:0008144; drug binding
GO pathway annotationGO:0015276; ligand-gated ion channel activity
GO pathway annotationGO:0015464; acetylcholine receptor activity
GO pathway annotationGO:0016021; integral component of membrane
GO pathway annotationGO:0030054; cell junction
GO pathway annotationGO:0034220; ion transmembrane transport
GO pathway annotationGO:0035094; response to nicotine
GO pathway annotationGO:0035095; behavioral response to nicotine
GO pathway annotationGO:0042166; acetylcholine binding
GO pathway annotationGO:0043005; neuron projection
GO pathway annotationGO:0045211; postsynaptic membrane
GO pathway annotationGO:0046928; regulation of neurotransmitter secretion
GO pathway annotationGO:0046982; protein heterodimerization activity
GO pathway annotationGO:0051291; protein heterooligomerization
GO pathway annotationGO:0051971; positive regulation of transmission of nerve impulse
GO pathway annotationGO:0060084; synaptic transmission involved in micturition
GO pathway annotationGO:0098655; cation transmembrane transport
Co-expression Information

There is no gene co-express this gene!

Expression pattern

There is no expression information about these genes!

Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction