Basic Information
Gene SymbolCHRNB2
Entrez Id1141
Descriptioncholinergic receptor, nicotinic, beta 2 (neuronal)
Gene typeprotein-coding
SNP Information


  Note: RegulomeDB score*
score supporting data score supporting data
1aeQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak6other
2aTF binding + matched TF motif + matched DNase Footprint + DNase peak5TF binding or DNase peak
1beQTL + TF binding + any motif + DNase Footprint + DNase peak4TF binding + DNase peak
2bTF binding + any motif + DNase Footprint + DNase peak3bTF binding + matched TF motif
1ceQTL + TF binding + matched TF motif + DNase peak1feQTL + TF binding / DNase peak
2cTF binding + matched TF motif + DNase peak3aTF binding + any motif + DNase peak
1deQTL + TF binding + any motif + DNase peak1eeQTL + TF binding + matched TF motif
CNV Information

The gene is not affected by CNV!

eQTL Information

There is no eQTL snp about this gene!

KEGG annotation
KEGG pathway annotationhsa04080; Neuroactive ligand-receptor interaction
KEGG pathway annotationhsa04725; Cholinergic synapse
KEGG pathway annotationhsa05033; Nicotine addiction
GO annotation
GO pathway annotationGO:0001508; action potential
GO pathway annotationGO:0001661; conditioned taste aversion
GO pathway annotationGO:0001666; response to hypoxia
GO pathway annotationGO:0004889; acetylcholine-activated cation-selective channel activity
GO pathway annotationGO:0005515; protein binding
GO pathway annotationGO:0005886; plasma membrane
GO pathway annotationGO:0005892; acetylcholine-gated channel complex
GO pathway annotationGO:0006811; ion transport
GO pathway annotationGO:0006816; calcium ion transport
GO pathway annotationGO:0006939; smooth muscle contraction
GO pathway annotationGO:0007165; signal transduction
GO pathway annotationGO:0007268; synaptic transmission
GO pathway annotationGO:0007271; synaptic transmission, cholinergic
GO pathway annotationGO:0007274; neuromuscular synaptic transmission
GO pathway annotationGO:0007601; visual perception
GO pathway annotationGO:0007605; sensory perception of sound
GO pathway annotationGO:0007612; learning
GO pathway annotationGO:0007613; memory
GO pathway annotationGO:0007626; locomotory behavior
GO pathway annotationGO:0008144; drug binding
GO pathway annotationGO:0008306; associative learning
GO pathway annotationGO:0008542; visual learning
GO pathway annotationGO:0009897; external side of plasma membrane
GO pathway annotationGO:0014059; regulation of dopamine secretion
GO pathway annotationGO:0015276; ligand-gated ion channel activity
GO pathway annotationGO:0015464; acetylcholine receptor activity
GO pathway annotationGO:0016021; integral component of membrane
GO pathway annotationGO:0019233; sensory perception of pain
GO pathway annotationGO:0021562; vestibulocochlear nerve development
GO pathway annotationGO:0021631; optic nerve morphogenesis
GO pathway annotationGO:0021771; lateral geniculate nucleus development
GO pathway annotationGO:0021952; central nervous system projection neuron axonogenesis
GO pathway annotationGO:0030054; cell junction
GO pathway annotationGO:0030890; positive regulation of B cell proliferation
GO pathway annotationGO:0032225; regulation of synaptic transmission, dopaminergic
GO pathway annotationGO:0032226; positive regulation of synaptic transmission, dopaminergic
GO pathway annotationGO:0033603; positive regulation of dopamine secretion
GO pathway annotationGO:0034220; ion transmembrane transport
GO pathway annotationGO:0035094; response to nicotine
GO pathway annotationGO:0035095; behavioral response to nicotine
GO pathway annotationGO:0035176; social behavior
GO pathway annotationGO:0042053; regulation of dopamine metabolic process
GO pathway annotationGO:0042113; B cell activation
GO pathway annotationGO:0042166; acetylcholine binding
GO pathway annotationGO:0042220; response to cocaine
GO pathway annotationGO:0042320; regulation of circadian sleep/wake cycle, REM sleep
GO pathway annotationGO:0045188; regulation of circadian sleep/wake cycle, non-REM sleep
GO pathway annotationGO:0045211; postsynaptic membrane
GO pathway annotationGO:0045471; response to ethanol
GO pathway annotationGO:0045759; negative regulation of action potential
GO pathway annotationGO:0046982; protein heterodimerization activity
GO pathway annotationGO:0048814; regulation of dendrite morphogenesis
GO pathway annotationGO:0050877; neurological system process
GO pathway annotationGO:0050890; cognition
GO pathway annotationGO:0051291; protein heterooligomerization
GO pathway annotationGO:0051899; membrane depolarization
GO pathway annotationGO:0051963; regulation of synapse assembly
GO pathway annotationGO:0060084; synaptic transmission involved in micturition
GO pathway annotationGO:0098655; cation transmembrane transport
Co-expression Information

There is no gene co-express this gene!

Expression pattern
Note: Avg - average expression of all genes
Description Age Description Age Description Age
Embryonic4-8 PCWEarly fetal18-10 PCWEarly fetal210-13 PCW
Early mid-fetal113-16 PCWEarly mid-fetal216-19 PCWLate mid-fetal19-24 PCW
Late fetal24-38 PCWNeonatal & early infancy0-6 MLate infancy6-12 M
Early childhood1-6 YMiddle and late childhood6-12 YAdolescence12-20 Y
Young adulthood20-40 YMiddle adulthood40-60 YLate adulthood60 Y+
Protein-protein interaction

There is no PPI information about this gene in InWeb